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Clenbuterol is a β 2 agonist/antagonist bronchodilator marketed as Ventipulmin ® and is the only member of this group of drugs approved by the US Food and Drug Administration (FDA) for use in horses. Abstract Clenbuterol is a beta (2)-agonist and potent selective bronchodilator that is used to treat bronchospasm in the horse. The drug is normally administered to horses orally as a syrup formulation. Chronic clenbuterol administration is believed to be ergogenicthrough the production of increased muscle mass, butparadoxically, this effect appears to impair exercise capacity. Clenbuterol results in significant repartitioning in horses whenadministered at the recommended doses, both alone and incombination with exercise. Clenbuterol positives lead to HISA penalty for trainer Taylor. HRN Staff July 20, 2023 12:34pm. Trainer Joseph Taylor was provisionally suspended by the Horseracing Integrity & Welfare Unit after two of his horses tested positive for methylphenidate and clenbuterol after racing at Parx. Chronic use may have adverse effects on cardiac function in healthy horses. There have been conflicting studies on the effects of clenbuterol on athletic performance of horses. In one study at approved doses, it did not have any adverse effects on equine cardiac or skeletal muscle. These observations suggest that intratracheal administration of clenbuterol shortly before race time can be detected with this serum test. Traditionally, equine drug testing has been dependent on urine testing because of the small volume of serum samples and the low concentrations of drugs found therein Clenbuterol is not a supplement that should be taken all year round, clenbuterol testing in horses.

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