Ranitidine Tablet 150 mg, once a popular medication, belongs to a class of drugs called H2 blockers. It was widely used to reduce stomach acid and treat various gastrointestinal conditions. However, recent safety concerns have significantly impacted its availability. This article provides a comprehensive overview of ranitidine, covering its uses, dosage, potential side effects, and safety warnings.

What is Ranitidine?

Ranitidine works by blocking histamine H2 receptors in the stomach lining, which reduces the production of stomach acid. It was commonly prescribed for conditions such as:

• Gastroesophageal reflux disease (GERD): Reduces acid reflux, alleviating heartburn and irritation.
• Peptic ulcers: Promotes healing of ulcers in the stomach or duodenum and prevents recurrence.
• Zollinger-Ellison syndrome: Treats excessive acid production due to tumors.
• Dyspepsia: Provides relief from indigestion and bloating.

Ranitidine was available in both prescription and over-the-counter (OTC) forms, with strengths ranging from 75 mg to 300 mg.

Dosage and Administration

General Guidelines

The dosage of ranitidine varies based on the condition being treated, patient age, and individual health factors. Here are general recommendations:

• For GERD:
• Adults: 150 mg twice daily or 300 mg at bedtime.
• Children: Doses are weight-based and determined by a doctor.
• For Peptic Ulcers:
• Adults: 150 mg twice daily or 300 mg at bedtime for 4–8 weeks. Maintenance dose: 150 mg at bedtime.
• For Zollinger-Ellison Syndrome:
• Adults: Start with 150 mg twice daily; adjust based on response.
• For Dyspepsia (OTC use):
• Adults and children over 12: 75 mg to 150 mg before eating or when symptoms occur.

Administration Tips:

• Take ranitidine with or without food.
• If taking it once daily, it’s best to do so at bedtime.
• Follow your healthcare provider’s instructions carefully.

Side Effects

Buy Ranitidine is generally well-tolerated, but like any medication, it can cause side effects.

Common Side Effects:

• Headache
• Dizziness
• Constipation or diarrhea
• Nausea or vomiting

Less Common but Serious Side Effects:

• Abnormal heart rhythm
• Liver dysfunction, indicated by jaundice or dark urine
• Severe allergic reactions, such as rash, swelling, or difficulty breathing

Long-Term Use Concerns:

Prolonged use of acid-reducing medications, including ranitidine, may lead to:

• Vitamin B12 deficiency
• Bone fractures due to impaired calcium absorption

If you experience any severe side effects, discontinue use and seek medical attention immediately.

Warnings and Safety Concerns

In 2019, the U.S. Food and Drug Administration (FDA) issued warnings about ranitidine due to concerns over NDMA (N-Nitrosodimethylamine) contamination. NDMA is a probable human carcinogen, leading to the recall of ranitidine products worldwide.

Key Safety Warnings:

1. Availability and Recalls:
   • Ranitidine has been withdrawn from many markets. Safer alternatives, such as famotidine, are now recommended.
2. Pregnancy and Breastfeeding:
   • Use during pregnancy or breastfeeding should be under strict medical supervision.
3. Kidney and Liver Disease:
   • Patients with these conditions may need dosage adjustments or alternative medications.
4. Drug Interactions:
   • Ranitidine may interact with medications like warfarin, ketoconazole, and atazanavir, altering their effectiveness.

Alternatives to Ranitidine

Given safety concerns, healthcare providers often recommend alternatives, such as:

• H2 blockers: Famotidine, cimetidine.
• Proton pump inhibitors (PPIs): Omeprazole, lansoprazole.

Precautions

To ensure safety while using ranitidine or any acid-reducing medication, follow these precautions:

• Inform Your Doctor:
• Discuss your complete medical history, including any allergies or current medications.
• Avoid Self-Medication:
• Do not take ranitidine for prolonged periods without consulting a healthcare provider.
• Lifestyle Modifications:
• Incorporate dietary and lifestyle changes to manage acid reflux and ulcers effectively, such as:
  • Avoiding spicy and fatty foods.
  • Reducing alcohol and caffeine intake.
  • Eating smaller, more frequent meals.

Overdose and Missed Doses

Overdose Symptoms:

Taking too much ranitidine may cause:

• Severe dizziness
• Low blood pressure
• Confusion

Seek emergency medical attention in case of an overdose.

Missed Dose:

If you forget a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue as usual. Never double the dose to make up for a missed one.

Frequently Asked Questions (FAQs)

1. Why was ranitidine removed from the market?

Ranitidine was recalled due to NDMA contamination, which posed potential cancer risks.

2. What are safer alternatives to ranitidine?

Famotidine and PPIs like omeprazole are commonly used as safer options.

3. Can I still use ranitidine if I have some at home?

Consult your doctor before using ranitidine, as alternatives may be safer and more effective.

4. Is ranitidine safe for children?

It was approved for pediatric use in certain conditions, but alternatives are now preferred due to safety concerns.

Conclusion

Ranitidine was once a cornerstone in treating acid-related gastrointestinal conditions. While effective, concerns over its safety led to its discontinuation in many regions. Safer alternatives like famotidine and PPIs have replaced it for most patients. If you have questions about ranitidine or its substitutes, consult your healthcare provider for personalized advice. Always prioritize safety and stay informed about the medications you use.