Profacgen, a leading provider of computational protein modeling services, today announced that it has updated its fusion protein modeling service. The enhanced service utilizes advanced computational methods to predict the three-dimensional structure of fusion proteins, which are critical in both research and therapeutic applications.

Fusion proteins, created through recombinant DNA technology, combine two or more protein domains into a single entity. These proteins play a vital role in labeling proteins of interest, facilitating purification, improving solubility and stability, enhancing enzyme reaction rates, and developing innovative therapeutics. However, the complex structure of fusion proteins often makes experimental determination of their 3D structure challenging.

Profacgen’s updated fusion protein modeling service addresses this challenge by leveraging the known structures of individual fusion partners to direct the computational modeling process. The service involves selecting the protein components to be fused, connecting these partners using linkers or domain insertion strategies, and then computationally sampling the conformations of bridging regions to generate an initial fusion model. The final models are refined to eliminate steric clashes, with the option to include ligands, cofactors, and water.

A key feature of the service is intensive sampling of the flexible regions between fusion components. This allows the protein domains to move, rotate, and interact to reach a stable conformation. The service also includes prediction of physical properties and quality assessment by multiple criteria.

“We are excited to offer this updated service to our customers,” said Crystal, the chief marketing staff at Profacgen. “Our team of experts has extensive experience with computational protein modeling techniques, ensuring that the fusion partners are physiochemically compatible and the predictions are testable in laboratory experiments.”

The fusion protein modeling service is fully customizable to meet specific customer requirements. Profacgen works closely with clients to understand their needs and design a modeling protocol accordingly. The resultant models can be used in downstream computational simulations as well as for the design and engineering of novel fusion proteins with desired functionalities.

In addition to fusion protein modeling, Profacgen offers a range of protein structure modeling services, including Homology Modeling, Membrane Protein Modeling, Antibody Modeling, Post-translational Modification, and Fold Recognition. These services utilize computational methods to predict the 3D structure of proteins, which provides essential information about their biological function and facilitates the design of therapeutic drugs. The protein structure models generated by Profacgen are all quality validated and can be used for a variety of purposes, including annotation of genes with unknown function and structure-based drug design.

For more information about Profacgen’s protein structure modeling services, including fusion protein modeling, please visit https://www.profacgen.com/Protein-Structure-Modeling.htm.